人类行为和心理机制图书
Human Behavior and Psychological Mechanism: Attentional Modulation of Sensory Gating
[内容简介] 本书使用听觉知觉空间分离这个范式，围绕高层次注意对低层次感觉门控的调节作用及其机制展开，分别以正常人类被试、慢性精神分裂症患者以及实验大鼠为研究对象，通过人类心理物理学、动物行为测量和神经药物局部阻断等方法，系统研究了感觉门控体系信息加工的层次性及其内在的神经机制，考察了高层次注意对低层次感觉门控的调节及其机制。
相关信息
致谢
第一章 绪论
第一节 研究目的和意义
第二节 研究现状和基本概念
一 感觉门控
二 惊反射
三 前脉冲抑制
四 前脉冲抑制与精神分裂症
五 前脉冲抑制的注意调节与精神分裂症
六 高级认知过程对前脉冲抑制的调节
七 听觉优先效应、知觉空间分离和空间选择性注意
（一）优先效应
（二）基于优先效应的知觉空间分离
第三节 问题的提出和本书的组织
一 正常被试知觉空间分离对PPI的调节
二 知觉空间分离对PPI调节的皮层加工机制
三 慢性精神分裂症患者知觉空间分离对PPI的调节
四 实验大鼠知觉空间分离对PPI的调节及空间特异性
五 实验大鼠知觉空间分离调节PPI的关键脑区
第四节 研究方法说明
一 实验对象
二 实验刺激
三 实验手段
第二章 知觉空间分离对前脉冲抑制的调节
第一节 知觉空间分离对前脉冲抑制调节的行为范式
一 引言
二 实验方法
（一）被试
（二）实验刺激和设备
（三）实验程序
（四）数据分析
三 实验结果
（一）行为实验结果
（二）对单纯惊刺激的惊反射
（三）知觉空间分离对PPI的调节
四 讨论
（一）主要发现
（二）知觉空间分离对PPI的增强作用
（三）惊反射和PPI的性别差异
五 小结
第二节 知觉空间分离对前脉冲抑制调节的时间特性
一 引言
二 实验方法
（一）被试
（二）实验刺激和设备
（三）实验程序
（四）数据分析
三 实验结果
四 讨论
（一）主要发现
（二）知觉空间分离对PPI调节的时间特性
五 小结
第三章 知觉空间分离增强前脉冲抑制的皮层加工机制
第一节 引言
第二节 实验方法
一 知觉空间分离调节PPI实验
（一）被试
（二）实验刺激和设备
（三）实验程序
（四）数据分析
二 知觉空间分离去掩蔽的神经相关物实验
（一）被试
（二）实验刺激和设备
（三）实验程序
（四）EEG数据记录与分析
第三节 实验结果
一 知觉空间分离对PPI的调节作用
二 知觉空间分离对目标刺激的皮层诱发电位的调节作用
（1）N1峰值比较
（2）N1潜伏期比较
（3）P2峰值比较
（4）P2潜伏期比较
（5）N1-P2峰峰值比较
三 知觉空间分离对目标刺激皮层诱发电位的调节与对PPI调节的关系
（1）知觉空间重合条件下的PPI
（2）知觉空间分离条件下的PPI
（3）知觉空间分离与知觉空间重合条件下的差值PPI
第四节 讨论
一 知觉空间分离去掩蔽的神经生理机制
二 知觉空间分离调节PPI的神经生理机制
第五节 小结
第四章 慢性精神分裂症患者知觉空间分离对前脉冲抑制的调节
第一节 引言
第二节 实验方法
一 被试
二 实验刺激和设备
三 实验程序
四 数据分析
第三节 实验结果
一 患者和对照组的一般人口学特征和临床测评结果
二 患者和对照组的行为实验结果
三 患者和对照组对单纯惊刺激的惊反射
四 患者和对照组PPI的值
五 精神分裂症患者惊反射、PPI、注意增强PPI效应和临床特征、人口学特征之间的关系
（一）惊反射、PPI、PPI注意增量和临床特征的关系
（二）惊反射、PPI的值、PPI注意增量和一般人口学特征的关系
（三）PPI的基线值与临床症状和人口学特征之间的关系
（1）相关分析
（2）精神症状严重程度对患者PPI的影响
（3）疾病分型对患者PPI的影响
（四）PPI的注意增强效应与临床症状和人口学特征之间的关系
（五）幻听和妄想对精神分裂症患者PPI及PPI注意增强效应的影响
第四节 讨论
一 主要发现
二 慢性精神分裂症患者的PPI
三 慢性精神分裂症患者的PPI 注意增强效应
四 精神分裂症可能的新的内表型指标
五 ISI对患者知觉空间分离调节PPI的影响
第五节 小结
第五章 实验大鼠知觉空间分离调节前脉冲抑制的空间特异性
第一节 引言
第二节 实验方法
一 被试
二 实验刺激和设备
三 实验程序
（1）适应
（2）PPI的前测
（3）恐惧条件化/条件化控制
（4）PPI的学习后测
（5）药物注射+消退学习
（6）PPI的消退后测
四 数据分析
第三节 实验结果
一 单独呈现惊刺激时惊反射的幅度变化
二 恐惧条件化对PPI的调节
（一）恐惧条件化/生理盐水组
（二）恐惧条件化/MPEP组
三 条件化控制对PPI的调节
第四节 讨论
一 主要发现
二 惊反射的提高
三 恐惧条件化对PPI的调节不具有空间特异性
四 知觉空间分离对PPI的调节具有空间特异性
五 mGluR5和恐惧消退学习对PPI的调节
六 PPI自上而下调节的空间方向特异性与精神分裂症新的动物模型
第五节 小结
第六章 实验大鼠知觉空间分离调节前脉冲抑制的关键脑区：后顶叶
第一节 引言
第二节 实验方法
一 被试
二 实验刺激和设备
三 药物注射
四 实验程序
五 数据分析
六 组织学检查
第三节 实验结果
一 组织学结果
二 恐惧条件化和知觉空间分离对PPI的调节
三 单侧后顶叶在知觉空间分离调节PPI中的作用
四 后顶叶对PPI影响的解剖特异性
第四节 讨论
一 主要发现
二 后顶叶在PPI调节中的作用
第五节 小结
第七章 总结与展望
第一节 建立一种新的注意调节前脉冲抑制的模型
第二节 感觉门控体系信息加工的层次性
第三节 注意调节前脉冲抑制的神经机制
第四节 注意调节前脉冲抑制的影响因素
第五节 慢性精神分裂症患者注意对前脉冲抑制的调节
第六节 本书的创新点
第七节 未来工作展望
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